More than 2,500 published studies worldwide support laser therapy, with over 100 double-blind studies published. There are several effects that have been observed with therapeutic lasers, and phototherapy in general, that make laser therapy unique among the various healing modalities available today. Photobiomodulation produces changes in oxidation/reduction status of the mitochondria which lead to substantial increases in ATP synthesis. Activation of the sodium/potassium pump alters the cell membrane permeability.